Four people were killed and an unknown number injured after an Amtrak train collided with a dump truck and derailed in Missouri.

Editor’s Note: This article was originally published at 4:48pm on Monday, June 27th, and has since been updated with new information.

Three of those killed were passengers on the train, while the third was riding in the truck that was struck, .

The Missouri State Highway Patrol says about 150 people were taken to 10 hospitals to be treated for injuries that range “from minor to serious in nature.”

Southwest Chief Train 4 at a public crossing with no lights or signals in the city of Mendon, Missouri around 12:42 p.m. central time, according to officials. On board the train were 243 passengers and 12 crew members when the incident happened, according to a from Amtrak.

All in all, Amtrak says eight cars and two locomotives came off the tracks. Most of the passenger cars were shown laying on their side in witness video and photos.

“Local authorities are currently assisting customers. Our Incident Response Team has been activated, and we are deploying emergency personnel to the scene to help support our passengers, our employees and their families with their needs,” the release from Amtrak said.

The train originally departed from Los Angeles en route to Chicago and went off the rails in the small town of Mendon about 100 miles northeast of Kansas City. Mendon has a population of about 162 people.

No other information was available from Amtrak at the time of publication.

One Twitter user, Dax McDonald, says passengers on board were bussed to a local high school.

According to , Chillicothe Fire Department Chief Eric Reeter confirmed the derailment and said they are on standby.

This is the second Amtrak collision in just two days. On Sunday, 85 people were on board a train in rural California that hit a passenger car at an unmarked crossing with no signals. , all of them riding in the car that was struck, CNN reports.